Host Louisville Mercy closed the game on an 11-1 run to hand Elizabethtown its second loss of the season, 72-61 on Tuesday.
The Lady Panthers (10-2) lost for the first time since a 46-44 setback to Nelson County on Dec. 8.
Senior guard Kaylyn Cecil paced Elizabethtown with 16 points, while eighth-grade forward Erin Boley added 11 points, six rebounds and one assist. Freshman post Reaunna Cleaver chipped in with 10 points and four rebounds.
The Lady Panthers led 55-53 in the third quarter, but the Jaguars closed the period with a 6-0 run.